Application of Enzyme-Linked Immunosorbent Assay (ELISA) in Neuroscience Research

Application of Enzyme-Linked Immunosorbent Assay

Neuroscience is to understand the molecular level, cellular level, and cell-to-cell changes in the nervous system, and the integration of these processes in the central functional control system. Basic neuroscience includes areas such as molecular neurobiology, cellular neurobiology, systems neurobiology, behavioural neurobiology, developmental neurobiology, and comparative neurobiology. Clinical neuroscience focuses on the clinical application of medicine, mainly studying diseases related to the nervous system, as well as diagnosis, treatment methods, and techniques. Neuroscience involves a large number of neurons, glial cells, and neurotransmitters that transmit signals. Neurons are non-renewable, trauma, disease and environmental toxins will cause the death of a large number of neurons. Glial cells, the number of which is about 5-10 times that of neuronal cells, are mainly used to support the structure and repair of the brain. Neuroscience is more complex than any other field of biology. ELISA with high sensitivity and strong specificity is used in neuroscience, which is helpful for people's research in this field.

Common Targets in Neuroscience Research

  • Acetylcholine
  • Aginine Vasopressin
  • Acetylcholinesterase
  • Acetylcarnitine
  • Amyloid Precursor Protein
  • Brevican
  • Battenin
  • Beta-Endorphin
  • Butyrylcholinesterase
  • Brain Natriuretic Peptide
  • Calretinin
  • Calpastatin
  • Calsyntenin 2
  • Carboxylesterase 1
  • Calcium Sensing Receptor

Advantages of ELISA in Neuroscience Research

As an immunoassay method helpful for neuroscience research, ELISA has the following advantages

  • Contribute to research in the field of neuroscience
  • Can specifically detect many types of neurotransmitters
  • Help clarify the etiology and mechanism of nervous system diseases, and explore new treatment methods

Common Targets Detected by ELISA in Neuroscience Research


Acetylcholinesterase (AchE) has the activities of carboxypeptidase and aminopeptidase and is a key enzyme in nerve conduction. Between cholinergic synapses, the enzyme can degrade acetylcholine, stop the neurotransmitter's excitatory effect on the postsynaptic membrane, and ensure the normal transmission of nerve signals in the organism. AchE not only participates in the transmission of cholinergic neurotransmitters but also has neurotrophic factor-like effects that regulate and promote the development of nerve tissue and nerve regeneration.

Calcium Sensing Receptor

Calcium Sensing Receptor (CaSR) is a G protein-coupled receptor that senses nutrients and can be activated and regulated by a variety of endogenous or exogenous substances. CaSR is mainly located in the parathyroid glands. By regulating the secretion of parathyroid hormone, it maintains the homeostasis of calcium ions and other ions in the body. As a multifunctional regulator, CaSR participates in regulating cell growth, differentiation, apoptosis, ion channel opening, cell secretion, etc. It has become a potential target for disease treatment or prevention.

Brain Natriuretic Peptide

Brain natriuretic peptide (BNP), named after it was first isolated from pig brain by Japanese scholars. However, BNP is a member of the natriuretic peptide family mainly secreted by the heart. BNP is a polypeptide composed of 32 amino acid residues. It has important pathophysiological significance, can promote sodium excretion and urination, and has a strong vasodilator effect. The concentration of BNP in the determination can provide a lot of useful information for the clinic. Studies have shown that BNP is a biomarker of heart failure.

Creative Diagnostics has been committed to the application of ELISA in neuroscience. Relying on strong R&D capabilities and rich experience, we produce many ELISA kits products for neuroscience research, and we provide high-quality customized ELISA kits services, believable ELISA testing services, professional ELISA development services related to neuroscience according to your needs. If you want more information, please be at liberty to contact us.


  1. Shaikh, S.; et al. Current acetylcholinesterase-inhibitors: a neuroinformatics perspective. CNS Neurol Disord Drug Targets. 2014, 13(3): 391-401.
  2. Gardenal, E.; et al. Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease. Front Neurosci. 2017, 11: 81.
  3. Pharand, C.; et al. Brain natriuretic peptide in the management of heart failure: the versatile neurohormone. Chest. 2004, 125(2): 652-668.
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