Protein Characterization & Analysis Services
Protein characterization is a core element in modern life sciences and biopharmaceutical research and development. Our protein characterization and analysis services leverage multiple advanced analytical technologies and instrumentation platforms to provide comprehensive solutions for protein structural information, sequence identification, functional characterization, and quality assessment. Whether for basic research, drug development, or biopharmaceutical quality control, Creative Diagnostics designs flexible solutions tailored to your sample characteristics and analytical requirements, ensuring accurate and reliable data support.
Our Services
- High-Resolution Mass Spectrometry Platform
| Service | Technical Principle | Applications |
| Protein Identification & Quantification | Peptide Mass Fingerprinting (PMF) and MS/MS sequencing | Precise protein identification, functional domain mapping, relative or absolute quantification |
| Peptide Mapping Analysis | Site-specific enzymatic digestion (e.g., trypsin) followed by mass spectrometry | Quality control, batch consistency evaluation, sample similarity assessment |
| Post-Translational Modification (PTM) Characterization | High-resolution MS for precise localization and quantification of PTM sites | Protein function, stability, and bioactivity studies; applications in monoclonal antibodies, recombinant proteins, and biomarker research |
- Surface Plasmon Resonance (SPR) Platform
| Service | Technical Principle | Applications |
| Kinetic Parameter Analysis | Real-time monitoring of binding and dissociation kinetics; determination of ka, kd, and KD constants | Precise assessment of protein-ligand interaction strength and specificity |
| Affinity & Binding Specificity Assessment | Minute-scale affinity determination and comparative analysis | Support for protein engineering, antibody screening, and drug design |
| Binding Analysis & Specificity Verification | Detection of specific/non-specific binding and competitive inhibition | Validation of therapeutic protein target specificity and serological reagent cross-reactivity |
- Classical Characterization Techniques
| Service | Technical Principle | Applications |
| SDS-PAGE Electrophoresis | Protein separation under denaturing conditions based on molecular weight | Purity assessment, aggregation detection, degradation product identification, relative molecular weight estimation |
| Protein Blotting (Western Blotting) | SDS-PAGE combined with specific antibody detection | Protein-specific identification, PTM confirmation (e.g., phosphorylation status), sample quality verification |
| Protein Concentration Determination | Bradford or BCA assay methods | Accurate protein quantification for standardized analytical conditions |
Service Advantages
We integrate cutting-edge analytical instrumentation with classical characterization techniques to design flexible solutions tailored to your sample type and analytical objectives. Multi-platform analysis provides multidimensional, comprehensive protein characterization, maximizing scientific value from your samples. All instruments undergo regular maintenance and calibration, and our experienced analysts follow stringent operational protocols. We have established a comprehensive quality control system ensuring analytical accuracy and reproducibility to industry-leading standards. Beyond raw data provision, our professional team delivers scientific interpretation and biological significance analysis tailored to your research context. Our high-throughput platforms and optimized workflows enhance detection efficiency and shorten turnaround times while maintaining quality, with flexible pricing models to optimize your R&D costs. Throughout sample handling, we strictly adhere to operational standards, ensuring sample integrity and result traceability while maintaining strict client data confidentiality.
Service Workflow
After receiving your sample information and analytical requirements, our technical team conducts preliminary evaluation, assessing sample characteristics (protein type, concentration range, known modifications, etc.) and analytical objectives. We then propose tailored analytical schemes, ensuring both scientific rigor and practical feasibility.
Upon sample receipt, we perform necessary preliminary assessments (purity evaluation, concentration verification, etc.) to confirm samples meet analytical requirements. When needed, we perform appropriate sample preparation (buffer exchange, desalting, concentration, etc.) to ensure reliable analysis.
Following the established protocol, we systematically conduct each analytical measurement. Throughout this phase, we strictly follow operational standards and quality control protocols, continuously monitor data quality, and promptly adjust parameters or repeat measurements if anomalies are detected.
Raw data undergoes standardized processing and statistical analysis to eliminate noise and interference, ensuring result accuracy. We generate detailed data tables and visualization charts facilitating result interpretation and application.
We prepare professional analytical reports containing experimental methods, instrument parameters, raw data, processed results, statistical analysis, and detailed result interpretation with biological significance discussion.
Application
- Drug Development & Process Optimization
- Biomarker Discovery & Validation
- Basic Immunology & Signal Transduction Research
- Biopharmaceutical Quality Control & Stability Assessment
- Genetic Disease & Metabolic Disorder Research
- Food Safety & Nutritional Assessment
