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Integrated proteome/modificome and metabolome analysis is a core systems biology strategy that deeply connects the "regulatory layer" of cellular activity (proteins and their modifications) with the "functional phenotype layer" (metabolites). This service provides a panoramic view from molecular regulation to terminal phenotypic output, overcoming the limitations of single-omics approaches.
Our analysis is grounded in a fundamental biological principle: the state of the metabolic network is directly regulated by the abundance and activity of catalytic enzymes (proteins), whose activity is often precisely modulated by post-translational modifications (PTMs) such as phosphorylation and acetylation. By leveraging authoritative pathway databases like KEGG for integrated mapping and employing cross-omics correlation analysis, this service aims to achieve three key objectives:
We offer a one-stop solution from high-quality data generation to in-depth mechanistic interpretation.
| Analysis Module | Key Service Items | Core Deliverables |
| Proteomics Analysis | Global Qualitative & Quantitative Proteome Profiling | Protein identification & quantification, differential expressed protein screening, functional enrichment analysis (GO/KEGG). |
| Modificomics Analysis | Post-Translational Modification (PTM) Profiling | Identification & quantification of key PTM sites (phosphorylation, acetylation, ubiquitination, etc.), differential modified protein analysis, PTM-related pathway enrichment. |
| Metabolomics Analysis | Untargeted / Targeted Metabolomics Profiling | Broad-spectrum screening or precise quantification of small-molecule metabolites, differential metabolite screening, metabolic pathway enrichment analysis. |
| Core Integrated Analysis | Cross-Omics Correlation & Integration Analysis | 1. Pathway Integration Analysis: Co-mapping differential proteins/modified proteins and differential metabolites onto KEGG pathways to visualize regulatory-metabolic networks. 2. Correlation Network Construction: Calculate protein-metabolite expression correlations to build regulatory networks and identify hub molecules. |
The core advantage of this service lies in delivering deep systems biology insights from "regulatory cause" to "phenotypic effect." We go beyond just protein expression levels by incorporating modificomics to probe the regulation of functional activity, thereby establishing more causally suggestive links with metabolic phenotype changes. Our mature analysis pipeline ensures efficient integration of heterogeneous data, yielding discoveries with both statistical significance and biological relevance. Furthermore, we provide customized in-depth exploration tailored to your specific research focus.
Clarify the scientific question and design the optimal experimental and analysis plan.
Perform parallel or sequential extraction and quality control for proteins, PTMs, and metabolites.
Acquire omics data using high-precision mass spectrometry platforms.
Execute both individual omics analysis and core cross-omics integration analysis.
Provide a comprehensive analysis report accompanied by expert biological interpretation and actionable follow-up suggestions.
If you have a specific research direction or sample types in mind, please feel free to contact us for a customized proposal.
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