Medical Broad-Targeted Metabolomics is a high-throughput, precise quantitative metabolomic analysis technology specifically designed for medical research. This technology focuses on functional metabolites closely associated with health and disease in humans and commonly used animal models. It enables accurate quantification of over 1000 medically relevant, specialized metabolites. By comprehensively covering fifteen major metabolite categories (including but not limited to amino acids, lipids, bile acids, vitamins, hormones) and delving into core pathways such as energy metabolism, lipid metabolism, and amino acid metabolism, this technology provides a powerful and comprehensive solution for elucidating the metabolic mechanisms of disease development and for discovering and validating critical biomarkers.

Figure 1. Pathway analysis of validated and clustered metabolite. (Source: Mehanna M, et al. 2021)

Our Services

Creative Diagnostics offers a professional, one-stop Medical Broad-Targeted Metabolomics analysis service:

1. Targeted Quantitative Analysis: Precise quantification of over 1000 carefully selected functional metabolites highly relevant to medical research, based on high-resolution mass spectrometry platforms.

2. Comprehensive Metabolic Pathway Coverage: Analysis comprehensively spans fifteen major categories of key metabolites in humans and animals, ensuring systematic exploration of core pathways including energy metabolism, lipid metabolism, amino acid metabolism, nucleotide metabolism, and gut microbiota-related metabolism.

3. Biomarker Solution: Provides integrated research support from initial biomarker screening and discovery to subsequent targeted verification and analysis, accelerating the translation of scientific findings.

4. Broad Sample Compatibility: The service is widely applicable to various sample types from common medical research models such as humans, rats, and mice, including:

• Blood / Serum / Plasma
• Various Tissues (e.g., heart, liver, spleen, lung, kidney, brain)
• Cells & Cell Culture Supernatant
• Feces (suitable for gut microbiome metabolism studies)

5. Professional Data Analysis & Reporting: Provides comprehensive bioinformatics analysis, including data preprocessing, multivariate statistical analysis, differential metabolite screening, pathway enrichment analysis, and biomarker potential evaluation, culminating in a professional, easy-to-understand final report.

Service Advantages

• Medical Focus & High Relevance: The detection panel is optimized for medical research, targeting metabolites closely linked to physiological and pathological processes, yielding data of high scientific value.
• Accurate Quantification & Reliable Data: Utilizes isotope-labeled internal standards or multi-point calibration curves for absolute or relative quantification, ensuring data accuracy and reproducibility, meeting the requirements for high-impact publication.
• Balance of Throughput and Depth: Maintains high-throughput advantages while effectively detecting key mid-to-low abundance functional metabolites, preventing the omission of important signals.
• One-Stop Service: The entire process—from sample preparation and instrumental analysis to in-depth bioinformatics—is managed by our experienced technical team, allowing clients to focus solely on their scientific questions.
• Wide Applicability: Perfectly suited for various scenarios including basic medical research, drug efficacy and toxicity evaluation, and clinical translational research.

Workflow

Sample Submission Guidelines

To ensure statistical power and reliability of research findings, the following minimum biological replicate numbers are recommended for different sample types:

Note: The above are general guidelines. The specific number of replicates should be determined based on experimental design, effect size, and individual variability. We can provide further advice during the project design phase.