Neurotransmitter Profiling
Neurotransmitters are key chemical messengers in the brain and peripheral nervous system. They are primarily synthesized and released by neurons, transmitting signals across synapses to regulate a wide range of physiological processes, including movement, emotion, cognition, sleep, and stress response. Common neurotransmitters include acetylcholine, dopamine, norepinephrine, serotonin, histamine, glutamate, and GABA, spanning major classes such as choline compounds, biogenic amines, and amino acids.
Maintaining a balance of neurotransmitters is essential for normal nervous system function. Abnormal levels are closely associated with various neuropsychiatric disorders, such as depression, Alzheimer's disease, Parkinson's disease, schizophrenia, anxiety disorders, and epilepsy. Therefore, accurate detection of neurotransmitter changes holds significant value for researching disease mechanisms, discovering biomarkers, evaluating drug efficacy, and supporting clinical diagnosis.
Our Services
Creative Diagnostics provides professional and reliable targeted metabolomics services for neurotransmitter analysis based on a High-Performance Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) platform:
- Detection Coverage: Simultaneous and accurate qualitative and quantitative analysis of 17 key neurotransmitters and related metabolites, covering major neurotransmitter classes.
- Sample Types: Compatible with various biological samples, including serum, plasma, cerebrospinal fluid (CSF), tissue homogenates, and cell culture media.
- Methodology: Utilizes optimized sample preparation protocols and LC-MS/MS technology to ensure high sensitivity, accuracy, reproducibility, and high-throughput analysis.
- Data Analysis: Provides complete qualitative and quantitative results, including metabolite concentrations, differential analysis, and preliminary biological interpretation.
Service Advantages
Our service is built around LC-MS/MS technology, offering high sensitivity and specificity for the precise and reliable quantification of low-abundance neurotransmitters in diverse biological samples. Our thoroughly validated methods are high-throughput, significantly reducing project timelines. We provide end-to-end professional support, from experimental design to data interpretation, and implement stringent quality control throughout the entire process. This ensures highly accurate and reproducible data, delivering a solid foundation for your neuroscience research and translational applications.
Workflow
We collaborate with you to finalize the testing plan based on your research objectives and sample types.
We provide guidelines for sample collection and storage. Upon receipt, all samples undergo quality inspection.
Standardized sample preparation is performed, followed by LC-MS/MS analysis.
Qualitative and quantitative analysis is completed, and a detailed data report with preliminary interpretation is delivered.
We assist with result interpretation and visualization, supporting manuscript preparation and grant applications.
Application
- Disease Mechanism Research: Investigate neurotransmitter alterations in the development and progression of neuropsychiatric diseases.
- Drug Development & Efficacy Assessment: Monitor dynamic changes in neurotransmitter levels following pharmacological intervention.
- Biomarker Discovery: Identify disease-associated neurotransmitter biomarkers to aid in early diagnosis and subtyping.
- Neuroscience Research: Apply metabolomic insights to studies in brain science, behavior, and stress responses.
- Clinical Support: Provide metabolic-level data as a reference for psychiatric and neurological disorders.
As core molecules regulating nervous system function, the accurate profiling of neurotransmitters has become a vital tool in both neuroscience research and clinical exploration. We are committed to providing you with stable and precise targeted metabolomics solutions to empower your research and discoveries.
