Acylcarnitine Metabolomics Service

Acylcarnitines are a class of organic compounds formed by the conjugation of carnitine and fatty acids. They serve as crucial carriers in energy metabolism, playing a central role in mitochondrial fatty acid β-oxidation. They are responsible not only for transporting fatty acids into mitochondria for oxidation and energy production but also for shuttling out acyl groups generated during metabolism, thereby maintaining cellular metabolic balance. Recent research indicates that changes in acylcarnitine profiles are closely linked to neurological function, antioxidant defense, gene expression, and cell membrane stability, holding significant indicative value for understanding nervous system metabolism and the development of various metabolic diseases.

Figure 1. Representative structures of various acylcarnitine classes. (Source: Dambrova M, et al. 2022)

Our Services

Creative Diagnostics provides a comprehensive, one-stop targeted metabolomics solution for acylcarnitine analysis based on LC-MS/MS technology. Our service enables accurate qualitative and quantitative analysis of 42 key acylcarnitines in various biological samples, including serum, plasma, tissue, and cells. The service covers the entire workflow, from experimental design and sample testing to in-depth data analysis—including data preprocessing, differential metabolite screening, pathway enrichment, and biological functional interpretation. We also offer personalized technical support tailored to your specific research direction.

Service Advantages

• High Sensitivity and Accuracy: Our optimized chromatography-mass spectrometry method ensures stable detection and precise quantification of low-abundance metabolites.
• High-Throughput Detection: Capable of rapid processing of large sample batches, shortening project timelines.
• Professional and Reliable: The method demonstrates excellent stability and reproducibility. Strict quality control procedures guarantee data reliability.
• One-Stop Service: We provide end-to-end professional technical support and communication, from sample receipt to final report delivery.

Workflow

Applications

Acylcarnitine detection holds significant value in the following research areas:

• Disease Mechanism Studies: Particularly applicable for research related to mitochondrial dysfunction, inherited metabolic disorders (e.g., organic acidemias), neurodegenerative diseases, cardiovascular diseases, and metabolic syndromes such as diabetes.
• Drug Development & Efficacy Assessment: Evaluate the impact of drugs on energy metabolism pathways and discover potential biomarkers.
• Nutrition & Exercise Science: Investigate changes in the body's energy metabolism status under interventions like diet and exercise.
• Basic Research: Explore dynamic changes in energy metabolism during physiological and pathological processes in cellular or animal models.

Through our Targeted Acylcarnitine Metabolomics Service, you will obtain precise and reliable metabolic profile data, providing key technical support for a deeper understanding of energy metabolism regulation and related disease mechanisms. Feel free to reach out to discuss how we can collaborate to advance your research project.