Precise Immunoglobulin Detection Service
Immunoglobulins (Igs), or antibodies, are the central effector molecules and key biomarkers of the body's humoral immune response. Produced and secreted by B lymphocytes, they function like a highly specific "biological missile force," capable of recognizing, binding to, and aiding in the clearance of various pathogens (such as bacteria and viruses) and foreign substances that enter the body.
This service aims to systematically evaluate the functional status of humoral immunity by precisely quantifying the concentrations of the five main classes of immunoglobulins (IgG, IgA, IgM, IgD, IgE) in human serum. Detecting these indicators is of paramount importance for assisting in the diagnosis of various diseases, determining the type of infection, assessing immune status, and monitoring disease progression. It is an indispensable component of a comprehensive immune evaluation system.
Our Services
Creative Diagnostics provides comprehensive quantitative analysis of the immunoglobulin profile, with their clinical and research significance outlined in the table below:
| Detection Item | Key Characteristics & Functions | Brief Clinical Significance |
| IgG | The most abundant antibody in serum (75-80%), the main force in secondary immune responses and anti-infection defense; neutralizes toxins and activates complement. | Elevated: Seen in chronic infections, autoimmune diseases (e.g., SLE), liver diseases.
Reduced: Suggests humoral immunodeficiency, protein loss in nephrotic syndrome, immunosuppressant use. |
| IgA | Predominantly found on mucosal surfaces (respiratory, digestive tracts) and in secretions; serves as the first line of mucosal local immunity. | Elevated: Seen in mucosal infections, IgA nephropathy, liver cirrhosis.
Reduced: Seen in selective IgA deficiency, recurrent respiratory or gastrointestinal infections. |
| IgM | The largest antibody molecule; the first antibody produced during the primary immune response, playing a crucial role in the early stages of infection. | Elevated: Indicates acute infection (e.g., early viral hepatitis), primary biliary cholangitis, macroglobulinemia. |
| IgD | Function not fully understood; primarily part of the B cell membrane receptor. Present in very low concentrations in serum. | Elevated: May be associated with certain chronic infections or autoimmune diseases. Its clinical utility is still under investigation. |
| IgE | The least abundant antibody in serum; typically associated with Type I hypersensitivity (allergy) and defense against parasitic infections. | Significantly Elevated: A key indicator for diagnosing allergic diseases (e.g., allergic asthma, rhinitis) and parasitic infections. |
Service Advantages
Our strength lies in providing accurate and reliable quantitative analysis of immunoglobulins. Leveraging professional detection platforms, we ensure high accuracy and reproducibility for every result. We not only deliver precise data for individual indicators but also focus on the comprehensive analysis of the IgG, IgA, IgM, IgD, IgE profile, offering a more holistic interpretation of humoral immune function. From sample receipt to report issuance, the entire process follows standardized operating procedures and strict quality control. With a standard turnaround time of approximately one week, we efficiently meet the needs of both clinical auxiliary diagnosis and scientific research.
Workflow
The client contacts our technical service team to clarify testing requirements and sample information.
The client collects samples according to the guide, and ships them to the laboratory under cold-chain conditions (2-8°C).
The laboratory receives the samples, assigns unique identification codes, logs information, and checks sample condition.
Professional instrumentation is used for the quantitative detection of immunoglobulins. Raw data is obtained and preliminary calculations/analysis are performed.
After data review, a formal report is generated containing detailed measured values, reference ranges, and brief interpretive comments. The report is delivered to the client electronically.
Application
- Screening and Diagnosis of Immunodeficiency Diseases: Assessing primary or secondary humoral immunodeficiencies (e.g., hypogammaglobulinemia, selective IgA deficiency).
- Auxiliary Diagnosis of Infectious Diseases: Aiding in determining the stage and type of infection by analyzing the dynamic changes in IgM (acute phase) and IgG (convalescent/chronic phase).
- Monitoring of Autoimmune Diseases: Monitoring polyclonal immunoglobulin elevations commonly seen in active phases of diseases like Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis.
- Diagnosis of Allergic Diseases and Parasitic Infections: Serum total IgE level is a key reference index for screening allergies and parasitic infections.
- Auxiliary Diagnosis of Hematologic Diseases: Assisting in diagnosing monoclonal gammopathies such as Multiple Myeloma (M protein) and Waldenström's macroglobulinemia.
- Evaluation of Liver and Kidney Diseases: Serving as an auxiliary parameter for assessing impaired liver function or glomerular filtration.
