Bile Acid Analysis Service
Bile acids are the main components of bile, synthesized in the liver and stored in the gallbladder. After eating, bile acids are released into the small intestine, where they participate in lipid digestion and absorption. Most bile acids are reabsorbed into the liver via the enterohepatic circulation, while a small portion enters systemic circulation, acting as important signaling molecules involved in physiological processes such as metabolic regulation and immune response. Recent studies suggest that bile acids such as deoxycholic acid (DCA) and chenodeoxycholic acid (CDCA) may cross the blood-brain barrier and interact with the nervous system. Imbalances in bile acid metabolism are closely associated with hepatobiliary diseases, metabolic syndrome, intestinal inflammation, neurodegenerative diseases, and more. Therefore, accurate profiling of bile acids is essential for understanding their physiological and pathological mechanisms.
Our Services
Creative Diagnostics offers a professional and comprehensive targeted metabolomics solution for bile acid detection based on high-performance LC-MS/MS. This service enables accurate qualitative and quantitative analysis of up to 40 bile acid metabolites in various human or animal samples, including serum, plasma, bile, feces, and tissues. Our end-to-end support covers specialized sample preparation, high-sensitivity mass spectrometry detection, rigorous data processing, and in-depth bioinformatic interpretation, providing clients with integrated research data generation and insightful analysis.
Our Advantages
- High Sensitivity and Accuracy: Utilizing an optimized LC-MS/MS method with low detection limits and high reproducibility to ensure reliable data.
- High-Throughput Analysis: Capable of processing large sample batches efficiently, suitable for clinical cohort studies and animal experiments.
- Expert Analytical Team: Provides full support from experimental design to metabolic pathway integration, helping to uncover underlying mechanisms.
- Stringent Quality Control: Implements strict protocols throughout sample collection, processing, and detection to ensure consistent and comparable results.
Workflow
Clarify research objectives, sample types, and target metabolites.
Provide standardized guidelines for sample collection, preservation, and shipment.
Perform sample pretreatment, instrumental analysis, and quality control.
Deliver qualitative/quantitative results, differential analysis, clustering, and pathway enrichment analysis.
Provide a comprehensive report including methodology, result charts/graphs, and preliminary biological interpretation.
Application
- Disease Mechanism Research: Investigate the relationship between bile acid metabolism and hepatobiliary diseases, diabetes, obesity, inflammatory bowel disease, etc.
- Drug Development & Evaluation: Monitor changes in bile acid profiles under drug intervention to assess efficacy and toxicity.
- Nutrition & Health Studies: Analyze the effects of diet, probiotics, and other factors on bile acid metabolism.
- Neurometabolic Research: Explore the role of bile acids in the gut-brain axis and their potential links to neurological disorders.
