Human CK10/Cytokeratin 10 Ready-To-Use IHC Kit

Catalog No:

RTUI0098

Sample Type:

FFPE tissue

Storage:

Please store components at the temperatures indicated on the individual tubelabels.The kit is stable for 6 months from the date of receipt.

Size:

50T (including a control slide)

Notes:

The positive control slide provided in the kit allows you to be sure that the experimental set-up is working properly.
Do not allow slides to dry at any time during this procedure.
Please don't replace the matching reagents in this product with other manufacturers' products.
As DAB is a carcinogen, please take necessary precautions.
PBS (reagent 1) can be stored for one week at 4℃ after preparation; The antigen retrieval buffer (1×reagent 2) and the chromogenic agent (the mixture of reagents 7 and 8) should be prepared right before each assay.

Synonyms:

CK10, Ka10, KER10, KPP, KRT10, 56 kDa cytokeratin, BCIE, BIE, CK 10, CK-10, ck10, Cytokeratin 10, Cytokeratin 6B, Cytokeratin VIB, Cytokeratin-10, Cytokeratin10, EHK, k10, K1C10_HUMAN, Keratin 10, Keratin, Keratin type i cytoskeletal 10, Keratin type I cytoskeletal 59 kDa, Keratin-10, Keratin10, kpp, Krt 1 10, Krt 10, krt10 , type I cytoskeletal 10, Type I keratin Ka10, Keratin, type I cytoskeletal 10, Cytokeratin-10, K10.

Introduction:

Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (i.e., skin) and non-keratinizing cells (i.e. mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. At least 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8. 5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification.